In Vivo Evaluation of Suppocire Paracetamol Rectal Suppositories

To achieve successful delivery of drug locally as well as systematically rectal route has proved its potential. The main objective of this research work was to evaluate the in vivo performance of paracetamol Suppocire CP suppository. Initially, suppositories were prepared, evaluated for their physicochemical parameters and in vitro drug release. An in vivo investigation of paracetamol availability in rabbits was carried out in comparison with marketed paracetamol suppository and suspension in complete cross-over design. The comparison between the three different formulations in terms of whole blood concentration revealed that the extent of drug absorption from Suppocire suppository and marketed suppository is comparable and showed promise that product of similar characteristic can be formulated using an amphiphilic suppository base. Bioavailability study showed comparable absorption after rectal and oral administration. A rectal irritation study exhibited high irritation profile for marketed suppository to rectal mucosa as compared to Suppocire suppository which showed no irritation.